Statins Reduce Thoracic Aortic Aneurysm Growth in Marfan Syndrome Mice via Inhibition of the Ras‐Induced ERK (Extracellular Signal‐Regulated Kinase) Signaling Pathway

BACKGROUND: Statins reduce aneurysm growth in mouse models of Marfan syndrome, although the mechanism is unknown. In addition to reducing cholesterol, statins block farnesylation and geranylgeranylation, which participate in membrane‐bound G‐protein signaling, including Ras. We dissected the prenyla...

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Vydáno v:J Am Heart Assoc
Hlavní autoři: Sato, Tetsuya, Arakawa, Mamoru, Tashima, Yasushi, Tsuboi, Eitoshi, Burdon, Grayson, Trojan, Jeffrey, Koyano, Tiffany, Youn, Young‐Nam, Penov, Kiril, Pedroza, Albert J., Shabazzi, Mohammad, Palmon, Itai, Nguyen, Marie Noel, Connolly, Andrew J., Yamaguchi, Atsushi, Fischbein, Michael P.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6404178/
https://ncbi.nlm.nih.gov/pubmed/30571378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.118.008543
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