Divergent effects of canonical and non‐canonical TGF‐β signalling on mixed contractile‐synthetic smooth muscle cell phenotype in human Marfan syndrome aortic root aneurysms

Aortic root aneurysm formation is a cardinal feature of Marfan syndrome (MFS) and likely TGF‐β driven via Smad (canonical) and ERK (non‐canonical) signalling. The current study assesses human MFS vascular smooth muscle cell (SMC) phenotype, focusing on individual contributions by Smad and ERK, with...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Pedroza, Albert J., Koyano, Tiffany, Trojan, Jeffrey, Rubin, Adam, Palmon, Itai, Jaatinen, Kevin, Burdon, Grayson, Chang, Paul, Tashima, Yasushi, Cui, Jason Z., Berry, Gerry, Iosef, Cristiana, Fischbein, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7011150/
https://ncbi.nlm.nih.gov/pubmed/31886938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14921
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