Statins Reduce Thoracic Aortic Aneurysm Growth in Marfan Syndrome Mice via Inhibition of the Ras‐Induced ERK (Extracellular Signal‐Regulated Kinase) Signaling Pathway

BACKGROUND: Statins reduce aneurysm growth in mouse models of Marfan syndrome, although the mechanism is unknown. In addition to reducing cholesterol, statins block farnesylation and geranylgeranylation, which participate in membrane‐bound G‐protein signaling, including Ras. We dissected the prenyla...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Am Heart Assoc
Egile Nagusiak: Sato, Tetsuya, Arakawa, Mamoru, Tashima, Yasushi, Tsuboi, Eitoshi, Burdon, Grayson, Trojan, Jeffrey, Koyano, Tiffany, Youn, Young‐Nam, Penov, Kiril, Pedroza, Albert J., Shabazzi, Mohammad, Palmon, Itai, Nguyen, Marie Noel, Connolly, Andrew J., Yamaguchi, Atsushi, Fischbein, Michael P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2018
Gaiak:
Original Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6404178/
https://ncbi.nlm.nih.gov/pubmed/30571378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.118.008543
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