ALDH1A1 regulates postsynaptic μ–opioid receptor expression in dorsal striatal projection neurons and mitigates dyskinesia through transsynaptic retinoic acid signaling

Aldehyde dehydrogenase 1A1 (ALDH1A1), a retinoic acid (RA) synthase, is selectively expressed by the nigrostriatal dopaminergic (nDA) neurons that preferentially degenerate in Parkinson’s disease (PD). ALDH1A1–positive axons mainly project to the dorsal striatum. However, whether ALDH1A1 and its pro...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Pan, Jing, Yu, Jia, Sun, Lixin, Xie, Chengsong, Chang, Lisa, Wu, Junbing, Hawes, Sarah, Saez–Atienzar, Sara, Zheng, Wang, Kung, Justin, Ding, Jinhui, Le, Weidong, Chen, Shengdi, Cai, Huaibin
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6401150/
https://ncbi.nlm.nih.gov/pubmed/30837649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40326-x
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