Parkinson’s disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging

BACKGROUND: Multiple missense mutations in Leucine-rich repeat kinase 2 (LRRK2) are associated with familial forms of late onset Parkinson’s disease (PD), the most common age-related movement disorder. The dysfunction of dopamine transmission contributes to PD-related motor symptoms. Interestingly,...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Chen, Xi, Xie, Chengsong, Tian, Wotu, Sun, Lixin, Wang, Zheng, Hawes, Sarah, Chang, Lisa, Kung, Justin, Ding, Jinhui, Chen, Shengdi, Le, Weidong, Cai, Huaibin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7031993/
https://ncbi.nlm.nih.gov/pubmed/32075681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-020-00360-0
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