ALDH1A1 regulates postsynaptic μ–opioid receptor expression in dorsal striatal projection neurons and mitigates dyskinesia through transsynaptic retinoic acid signaling

Aldehyde dehydrogenase 1A1 (ALDH1A1), a retinoic acid (RA) synthase, is selectively expressed by the nigrostriatal dopaminergic (nDA) neurons that preferentially degenerate in Parkinson’s disease (PD). ALDH1A1–positive axons mainly project to the dorsal striatum. However, whether ALDH1A1 and its pro...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Pan, Jing, Yu, Jia, Sun, Lixin, Xie, Chengsong, Chang, Lisa, Wu, Junbing, Hawes, Sarah, Saez–Atienzar, Sara, Zheng, Wang, Kung, Justin, Ding, Jinhui, Le, Weidong, Chen, Shengdi, Cai, Huaibin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6401150/
https://ncbi.nlm.nih.gov/pubmed/30837649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40326-x
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