ALDH1A1 regulates postsynaptic μ–opioid receptor expression in dorsal striatal projection neurons and mitigates dyskinesia through transsynaptic retinoic acid signaling

Aldehyde dehydrogenase 1A1 (ALDH1A1), a retinoic acid (RA) synthase, is selectively expressed by the nigrostriatal dopaminergic (nDA) neurons that preferentially degenerate in Parkinson’s disease (PD). ALDH1A1–positive axons mainly project to the dorsal striatum. However, whether ALDH1A1 and its pro...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Pan, Jing, Yu, Jia, Sun, Lixin, Xie, Chengsong, Chang, Lisa, Wu, Junbing, Hawes, Sarah, Saez–Atienzar, Sara, Zheng, Wang, Kung, Justin, Ding, Jinhui, Le, Weidong, Chen, Shengdi, Cai, Huaibin
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2019
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6401150/
https://ncbi.nlm.nih.gov/pubmed/30837649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40326-x
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia