ALDH1A1 regulates postsynaptic μ–opioid receptor expression in dorsal striatal projection neurons and mitigates dyskinesia through transsynaptic retinoic acid signaling

Aldehyde dehydrogenase 1A1 (ALDH1A1), a retinoic acid (RA) synthase, is selectively expressed by the nigrostriatal dopaminergic (nDA) neurons that preferentially degenerate in Parkinson’s disease (PD). ALDH1A1–positive axons mainly project to the dorsal striatum. However, whether ALDH1A1 and its pro...

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Vydáno v:Sci Rep
Hlavní autoři: Pan, Jing, Yu, Jia, Sun, Lixin, Xie, Chengsong, Chang, Lisa, Wu, Junbing, Hawes, Sarah, Saez–Atienzar, Sara, Zheng, Wang, Kung, Justin, Ding, Jinhui, Le, Weidong, Chen, Shengdi, Cai, Huaibin
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6401150/
https://ncbi.nlm.nih.gov/pubmed/30837649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40326-x
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