Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson’s Disease-related Mutant α-synuclein

Mutations in α-synuclein and Leucine-rich repeat kinase 2 (LRRK2) are linked to autosomal dominant forms of Parkinson’s disease (PD). However, little is known about any potential pathophysiological interplay between these two PD-related genes. Here we show in transgenic mice that although over-expre...

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Autors principals: Lin, Xian, Parisiadou, Loukia, Gu, Xing-Long, Wang, Lizhen, Shim, Hoon, Sun, Lixin, Xie, Chengsong, Long, Cai-Xia, Yang, Wan-Jou, Ding, Jinhui, Chen, Zsu Zsu, Gallant, Paul E., Tao-Cheng, Jung-Hwa, Rudow, Gay, Troncoso, Juan C., Liu, Zhihua, Li, Zheng, Cai, Huaibin
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807409/
https://ncbi.nlm.nih.gov/pubmed/20064389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2009.11.006
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