ATM is activated by ATP depletion and modulates mitochondrial function through NRF1

Ataxia-telangiectasia (A-T) is an autosomal recessive disease caused by mutation of the ATM gene and is characterized by loss of cerebellar Purkinje cells, neurons with high physiological activity and dynamic ATP demands. Here, we show that depletion of ATP generates reactive oxygen species that act...

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Detaylı Bibliyografya
Yayımlandı:J Cell Biol
Asıl Yazarlar: Chow, Hei-Man, Cheng, Aifang, Song, Xuan, Swerdel, Mavis R., Hart, Ronald P., Herrup, Karl
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Rockefeller University Press 2019
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6400560/
https://ncbi.nlm.nih.gov/pubmed/30642892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201806197
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