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ATM is activated by ATP depletion and modulates mitochondrial function through NRF1
Ataxia-telangiectasia (A-T) is an autosomal recessive disease caused by mutation of the ATM gene and is characterized by loss of cerebellar Purkinje cells, neurons with high physiological activity and dynamic ATP demands. Here, we show that depletion of ATP generates reactive oxygen species that act...
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| Опубликовано в: : | J Cell Biol |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Rockefeller University Press
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6400560/ https://ncbi.nlm.nih.gov/pubmed/30642892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201806197 |
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