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ATM is activated by ATP depletion and modulates mitochondrial function through NRF1

Ataxia-telangiectasia (A-T) is an autosomal recessive disease caused by mutation of the ATM gene and is characterized by loss of cerebellar Purkinje cells, neurons with high physiological activity and dynamic ATP demands. Here, we show that depletion of ATP generates reactive oxygen species that act...

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Détails bibliographiques
Publié dans:J Cell Biol
Auteurs principaux: Chow, Hei-Man, Cheng, Aifang, Song, Xuan, Swerdel, Mavis R., Hart, Ronald P., Herrup, Karl
Format: Artigo
Langue:Inglês
Publié: Rockefeller University Press 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6400560/
https://ncbi.nlm.nih.gov/pubmed/30642892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201806197
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