Genomic aberrations in cell cycle genes predict progression of KIT-mutant gastrointestinal stromal tumors (GISTs)

BACKGROUND: Activating mutations of the receptor tyrosine kinase KIT are early events in the development of most gastrointestinal stromal tumors (GISTs). Although GISTs generally remain dependent on oncogenic KIT during tumor progression, KIT mutations alone are insufficient to induce malignant beha...

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Detalhes bibliográficos
Publicado no:Clin Sarcoma Res
Main Authors: Heinrich, Michael C., Patterson, Janice, Beadling, Carol, Wang, Yuexiang, Debiec-Rychter, Maria, Dewaele, Barbara, Corless, Christopher L., Duensing, Anette, Raut, Chandrajit P., Rubin, Brian, Ordog, Tamas, van de Rijn, Matt, Call, Jerry, Mühlenberg, Thomas, Fletcher, Jonathan A., Bauer, Sebastian
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6399846/
https://ncbi.nlm.nih.gov/pubmed/30867899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13569-019-0112-7
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