LMTK3 is essential for oncogenic KIT expression in KIT-mutant GIST and melanoma

Certain cancers, including gastrointestinal stromal tumor (GIST) and subsets of melanoma, are caused by somatic KIT mutations that result in KIT receptor tyrosine kinase constitutive activity, which drives proliferation. The treatment of KIT-mutant GIST has been revolutionized with the advent of KIT...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Klug, Lillian R., Bannon, Amber E., Javidi-Sharifi, Nathalie, Town, Ajia, Fleming, William H., VanSlyke, Judy, Musil, Linda, Fletcher, Jonathan A., Tyner, Jeffrey W., Heinrich, Michael C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6365197/
https://ncbi.nlm.nih.gov/pubmed/30242244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0508-5
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