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Combination Therapy for KIT-Mutant Mast Cells: Targeting Constitutive NFAT and KIT Activity

Resistant KIT mutations have hindered the development of KIT kinase inhibitors for treatment of patients with systemic mastocytosis. The goal of this research was to characterize the synergistic effects of a novel combination therapy involving inhibition of KIT and calcineurin phosphatase, a nuclear...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Macleod, Alison C., Klug, Lillian R., Patterson, Janice, Griffith, Diana J., Beadling, Carol, Town, Ajia, Heinrich, Michael C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5026483/
https://ncbi.nlm.nih.gov/pubmed/25253785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0830
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