Genomic aberrations in cell cycle genes predict progression of KIT-mutant gastrointestinal stromal tumors (GISTs)

BACKGROUND: Activating mutations of the receptor tyrosine kinase KIT are early events in the development of most gastrointestinal stromal tumors (GISTs). Although GISTs generally remain dependent on oncogenic KIT during tumor progression, KIT mutations alone are insufficient to induce malignant beha...

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Détails bibliographiques
Publié dans:Clin Sarcoma Res
Auteurs principaux: Heinrich, Michael C., Patterson, Janice, Beadling, Carol, Wang, Yuexiang, Debiec-Rychter, Maria, Dewaele, Barbara, Corless, Christopher L., Duensing, Anette, Raut, Chandrajit P., Rubin, Brian, Ordog, Tamas, van de Rijn, Matt, Call, Jerry, Mühlenberg, Thomas, Fletcher, Jonathan A., Bauer, Sebastian
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2019
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6399846/
https://ncbi.nlm.nih.gov/pubmed/30867899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13569-019-0112-7
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