Pro-apoptotic activity of bortezomib in gastrointestinal stromal tumor (GIST) cells

Gastrointestinal stromal tumors (GISTs) are caused by activating mutations in the KIT or PDGFRA receptor tyrosine kinase genes. Although more than 85% of GIST patients treated with the small molecule inhibitor imatinib mesylate (Gleevec®) achieve disease stabilization, complete remissions are rare a...

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Bibliographische Detailangaben
Hauptverfasser: Bauer, Sebastian, Parry, Joshua A., Mühlenberg, Thomas, Brown, Matthew F., Seneviratne, Danushka, Chatterjee, Payel, Chin, Anna, Rubin, Brian P., Kuan, Shih-Fan, Fletcher, Jonathan A., Duensing, Stefan, Duensing, Anette
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805033/
https://ncbi.nlm.nih.gov/pubmed/20028860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1449
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