Pro-apoptotic activity of bortezomib in gastrointestinal stromal tumor (GIST) cells

Gastrointestinal stromal tumors (GISTs) are caused by activating mutations in the KIT or PDGFRA receptor tyrosine kinase genes. Although more than 85% of GIST patients treated with the small molecule inhibitor imatinib mesylate (Gleevec®) achieve disease stabilization, complete remissions are rare a...

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Bibliografiske detaljer
Main Authors: Bauer, Sebastian, Parry, Joshua A., Mühlenberg, Thomas, Brown, Matthew F., Seneviratne, Danushka, Chatterjee, Payel, Chin, Anna, Rubin, Brian P., Kuan, Shih-Fan, Fletcher, Jonathan A., Duensing, Stefan, Duensing, Anette
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805033/
https://ncbi.nlm.nih.gov/pubmed/20028860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1449
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