Pro-apoptotic activity of bortezomib in gastrointestinal stromal tumor (GIST) cells

Gastrointestinal stromal tumors (GISTs) are caused by activating mutations in the KIT or PDGFRA receptor tyrosine kinase genes. Although more than 85% of GIST patients treated with the small molecule inhibitor imatinib mesylate (Gleevec®) achieve disease stabilization, complete remissions are rare a...

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Autores principales: Bauer, Sebastian, Parry, Joshua A., Mühlenberg, Thomas, Brown, Matthew F., Seneviratne, Danushka, Chatterjee, Payel, Chin, Anna, Rubin, Brian P., Kuan, Shih-Fan, Fletcher, Jonathan A., Duensing, Stefan, Duensing, Anette
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805033/
https://ncbi.nlm.nih.gov/pubmed/20028860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-1449
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