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Quadruple wild-type (WT) GIST: defining the subset of GIST that lacks abnormalities of KIT, PDGFRA, SDH, or RAS signaling pathways

A subset of GISTs lack mutations in the KIT/PDGFRA or RAS pathways and yet retain an intact succinate dehydrogensase (SDH) complex. We propose that these KIT/PDGFRA/SDH/RAS-P WT GIST tumors be designated as quadruple wild-type (WT) GIST. Further molecular and clinicophatological characterization of...

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Podrobná bibliografie
Vydáno v:Cancer Med
Hlavní autoři: Pantaleo, Maria A, Nannini, Margherita, Corless, Christopher L, Heinrich, Michael C
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4312123/
https://ncbi.nlm.nih.gov/pubmed/25165019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.325
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