Targeted Deep Sequencing Uncovers Cryptic KIT Mutations in KIT/PDGFRA/SDH/RAS-P Wild-Type GIST

Background: Gastrointestinal stromal tumors (GIST) are known to carry oncogenic KIT or PDGFRA mutations, or less commonly SDH or NF1 gene inactivation, with very rare cases harboring mutant BRAF or RAS alleles. Approximately 10% of GISTs are devoid of any of such mutations and are characterized by v...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Astolfi, Annalisa, Indio, Valentina, Nannini, Margherita, Saponara, Maristella, Schipani, Angela, De Leo, Antonio, Altimari, Annalisa, Vincenzi, Bruno, Comandini, Danila, Grignani, Giovanni, Secchiero, Paola, Urbini, Milena, Pantaleo, Maria Abbondanza
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7188756/
https://ncbi.nlm.nih.gov/pubmed/32391261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.00504
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