In vivo investigation of hyperpolarized [1,3-(13)C(2)]acetoacetate as a metabolic probe in normal brain and in glioma

Dysregulation in NAD(+)/NADH levels is associated with increased cell division and elevated levels of reactive oxygen species in rapidly proliferating cancer cells. Conversion of the ketone body acetoacetate (AcAc) to β-hydroxybutyrate (β-HB) by the mitochondrial enzyme β-hydroxybutyrate dehydrogena...

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Udgivet i:Sci Rep
Main Authors: Najac, Chloé, Radoul, Marina, Le Page, Lydia M., Batsios, Georgios, Subramani, Elavarasan, Viswanath, Pavithra, Gillespie, Anne Marie, Ronen, Sabrina M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6399277/
https://ncbi.nlm.nih.gov/pubmed/30833594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-39677-2
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