EXTH-20. HYPERPOLARIZED [2-(13)C] PYRUVATE TO [5-(13)C] GLUTAMATE AS BIOMARKERS OF IDH1 MUTANT GLIOMA RESPONSE TO TEMOZOLOMIDE THERAPY

Low-grade gliomas, driven by mutations in the cytosolic isocitrate dehydrogenase 1 (IDH1) gene, are less aggressive than primary glioblastoma, but nonetheless always recur and ultimately lead to patient death. The treatment of IDH1 mutant patients with Temozolomide (TMZ) improves survival, but there...

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Bibliographic Details
Published in:Neuro Oncol
Main Authors: Subramani, Elavarasan, Najac, Chloe, Batsios, Georgios, Viswanath, Pavithra, Radoul, Marina, Marie Gillespie, Anne, Pieper, Russell O, Ronen, Sabrina
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847284/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.354
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