EXTH-35. IN VIVO (1)H MRS DETECTS REDUCED 2HG PRODUCTION IN IDH1 MUTANT GLIOMAS TREATED WITH A DUAL PI3K/MTOR INHIBITOR

70–90% of low-grade gliomas and secondary glioblastomas are characterized by mutations in isocitrate dehydrogenase (IDH1mut). Mutant IDH produces the oncometabolite 2-hydroxyglutarate (2HG), which drives tumorigenesis. Inhibitors of phosphoinositide-3-kinase (PI3K) pathway are currently under clinic...

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Publicado no:Neuro Oncol
Main Authors: Batsios, Georgios, Viswanath, Pavithra, Gillespie, Anne Marie, Subramani, Elavarasan, Phillips, Joanna J, Pieper, Russell, Ronen, Sabrina
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217306/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.384
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