MR-detectable metabolic biomarkers of response to mutant IDH inhibition in low-grade glioma

Mutations in isocitrate dehydrogenase 1 (IDH1mut) are reported in 70-90% of low-grade gliomas and secondary glioblastomas. IDH1mut catalyzes the reduction of α-ketoglutarate (α-KG) to 2-hydroxyglutarate (2-HG), an oncometabolite which drives tumorigenesis. Inhibition of IDH1mut is therefore an emerg...

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Publicat a:Theranostics
Autors principals: Molloy, Abigail R, Najac, Chloé, Viswanath, Pavithra, Lakhani, Aliya, Subramani, Elavarasan, Batsios, Georgios, Radoul, Marina, Gillespie, Anne Marie, Pieper, Russell O, Ronen, Sabrina M
Format: Artigo
Idioma:Inglês
Publicat: Ivyspring International Publisher 2020
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7392019/
https://ncbi.nlm.nih.gov/pubmed/32754276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.47317
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