In vivo detection of γ-glutamyl-transferase up-regulation in glioma using hyperpolarized γ-glutamyl-[1-(13)C]glycine

Glutathione (GSH) is often upregulated in cancer, where it serves to mitigate oxidative stress. γ-glutamyl-transferase (GGT) is a key enzyme in GSH homeostasis, and compared to normal brain its expression is elevated in tumors, including in primary glioblastoma. GGT is therefore an attractive imagin...

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Publicado en:Sci Rep
Autores principales: Batsios, Georgios, Najac, Chloé, Cao, Peng, Viswanath, Pavithra, Subramani, Elavarasan, Saito, Yutaro, Gillespie, Anne Marie, Yoshihara, Hikari A. I., Larson, Peder, Sando, Shinsuke, Ronen, Sabrina M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7148357/
https://ncbi.nlm.nih.gov/pubmed/32277103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-63160-y
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