CBMT-02. UP-REGULATION OF Γ-GLUTAMYL-TRANSFERASE CAN BE USED TO IMAGE GLIOBLASTOMA USING HYPERPOLARIZED Γ-GLUTAMYL-[1-(13)C]GLYCINE MRS

γ-glutamyl-transferase (GGT) is a key enzyme in the γ-glutamyl cycle, which regulates glutathione homeostasis. The enzyme is localized on the outer cell membrane and cleaves glutathione to glutamate and cysteinylglycine. As such, it facilitates uptake of the amino acids essential for intracellular s...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Batsios, Georgios, Najac, Chloe, Cao, Peng, Viswanath, Pavithra, Subramani, Elavarasan, Saito, Yutaro, Marie Gillespie, Anne, Yoshihara, Hikari, Larson, Peder, Sando, Shinsuke, Ronen, Sabrina
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Cell Biology and Metabolism
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847274/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.124
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