CBMT-02. UP-REGULATION OF Γ-GLUTAMYL-TRANSFERASE CAN BE USED TO IMAGE GLIOBLASTOMA USING HYPERPOLARIZED Γ-GLUTAMYL-[1-(13)C]GLYCINE MRS

γ-glutamyl-transferase (GGT) is a key enzyme in the γ-glutamyl cycle, which regulates glutathione homeostasis. The enzyme is localized on the outer cell membrane and cleaves glutathione to glutamate and cysteinylglycine. As such, it facilitates uptake of the amino acids essential for intracellular s...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Batsios, Georgios, Najac, Chloe, Cao, Peng, Viswanath, Pavithra, Subramani, Elavarasan, Saito, Yutaro, Marie Gillespie, Anne, Yoshihara, Hikari, Larson, Peder, Sando, Shinsuke, Ronen, Sabrina
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Cell Biology and Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847274/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.124
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