CBMT-02. UP-REGULATION OF Γ-GLUTAMYL-TRANSFERASE CAN BE USED TO IMAGE GLIOBLASTOMA USING HYPERPOLARIZED Γ-GLUTAMYL-[1-(13)C]GLYCINE MRS

γ-glutamyl-transferase (GGT) is a key enzyme in the γ-glutamyl cycle, which regulates glutathione homeostasis. The enzyme is localized on the outer cell membrane and cleaves glutathione to glutamate and cysteinylglycine. As such, it facilitates uptake of the amino acids essential for intracellular s...

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Détails bibliographiques
Publié dans:Neuro Oncol
Auteurs principaux: Batsios, Georgios, Najac, Chloe, Cao, Peng, Viswanath, Pavithra, Subramani, Elavarasan, Saito, Yutaro, Marie Gillespie, Anne, Yoshihara, Hikari, Larson, Peder, Sando, Shinsuke, Ronen, Sabrina
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Cell Biology and Metabolism
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6847274/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.124
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