Bladder decompensation and reduction in nerve density in a rat model of chronic bladder outlet obstruction are attenuated with the NLRP3 inhibitor glyburide

Bladder outlet obstruction (BOO) leads to progressive voiding dysfunction. Acutely, obstruction triggers inflammation that drives bladder dysfunction. Over time, inflammation leads to decreased bladder nerve density and increased fibrosis, responsible for eventual decompensation and irreversibility....

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Pubblicato in:Am J Physiol Renal Physiol
Autori principali: Hughes, Francis M., Sexton, Stephanie J., Ledig, Patrick D., Yun, Chloe E., Jin, Huixia, Purves, J. Todd
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6383202/
https://ncbi.nlm.nih.gov/pubmed/30353742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00400.2018
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