Bladder fibrosis during outlet obstruction is triggered through the NLRP3 inflammasome and the production of IL-1β

Bladder outlet obstruction (BOO) triggers inflammation in the bladder through the NLRP3 inflammasome. BOO also activates fibrosis, which is largely responsible for the decompensation of the bladder in the chronic state. Because fibrosis can be driven by inflammation, we have explored a role for NLRP...

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Detalhes bibliográficos
Publicado no:Am J Physiol Renal Physiol
Main Authors: Hughes, Francis M., Sexton, Stephanie J., Jin, Huixia, Govada, Vihasa, Purves, J. Todd
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625100/
https://ncbi.nlm.nih.gov/pubmed/28592436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00128.2017
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