Bladder fibrosis during outlet obstruction is triggered through the NLRP3 inflammasome and the production of IL-1β

Bladder outlet obstruction (BOO) triggers inflammation in the bladder through the NLRP3 inflammasome. BOO also activates fibrosis, which is largely responsible for the decompensation of the bladder in the chronic state. Because fibrosis can be driven by inflammation, we have explored a role for NLRP...

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Udgivet i:Am J Physiol Renal Physiol
Main Authors: Hughes, Francis M., Sexton, Stephanie J., Jin, Huixia, Govada, Vihasa, Purves, J. Todd
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625100/
https://ncbi.nlm.nih.gov/pubmed/28592436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00128.2017
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