Bladder decompensation and reduction in nerve density in a rat model of chronic bladder outlet obstruction are attenuated with the NLRP3 inhibitor glyburide

Bladder outlet obstruction (BOO) leads to progressive voiding dysfunction. Acutely, obstruction triggers inflammation that drives bladder dysfunction. Over time, inflammation leads to decreased bladder nerve density and increased fibrosis, responsible for eventual decompensation and irreversibility....

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Bibliografiske detaljer
Udgivet i:Am J Physiol Renal Physiol
Main Authors: Hughes, Francis M., Sexton, Stephanie J., Ledig, Patrick D., Yun, Chloe E., Jin, Huixia, Purves, J. Todd
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6383202/
https://ncbi.nlm.nih.gov/pubmed/30353742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00400.2018
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