Bladder decompensation and reduction in nerve density in a rat model of chronic bladder outlet obstruction are attenuated with the NLRP3 inhibitor glyburide

Bladder outlet obstruction (BOO) leads to progressive voiding dysfunction. Acutely, obstruction triggers inflammation that drives bladder dysfunction. Over time, inflammation leads to decreased bladder nerve density and increased fibrosis, responsible for eventual decompensation and irreversibility....

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Detalles Bibliográficos
Publicado en:Am J Physiol Renal Physiol
Autores principales: Hughes, Francis M., Sexton, Stephanie J., Ledig, Patrick D., Yun, Chloe E., Jin, Huixia, Purves, J. Todd
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2019
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6383202/
https://ncbi.nlm.nih.gov/pubmed/30353742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00400.2018
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