Bladder decompensation and reduction in nerve density in a rat model of chronic bladder outlet obstruction are attenuated with the NLRP3 inhibitor glyburide

Bladder outlet obstruction (BOO) leads to progressive voiding dysfunction. Acutely, obstruction triggers inflammation that drives bladder dysfunction. Over time, inflammation leads to decreased bladder nerve density and increased fibrosis, responsible for eventual decompensation and irreversibility....

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Veröffentlicht in:Am J Physiol Renal Physiol
Hauptverfasser: Hughes, Francis M., Sexton, Stephanie J., Ledig, Patrick D., Yun, Chloe E., Jin, Huixia, Purves, J. Todd
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6383202/
https://ncbi.nlm.nih.gov/pubmed/30353742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00400.2018
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