In vitro and in silico assessment of the developability of a designed monoclonal antibody library

Despite major advances in antibody discovery technologies, the successful development of monoclonal antibodies (mAbs) into effective therapeutic and diagnostic agents can often be impeded by developability liabilities, such as poor expression, low solubility, high viscosity and aggregation. Therefor...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:MAbs
Päätekijät: Wolf Pérez, Adriana-Michelle, Sormanni, Pietro, Andersen, Jonathan Sonne, Sakhnini, Laila Ismail, Rodriguez-Leon, Ileana, Bjelke, Jais Rose, Gajhede, Annette Juhl, De Maria, Leonardo, Otzen, Daniel E., Vendruscolo, Michele, Lorenzen, Nikolai
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Taylor & Francis 2019
Aiheet:
Report
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6380425/
https://ncbi.nlm.nih.gov/pubmed/30523762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1556082
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