In vitro and in silico assessment of the developability of a designed monoclonal antibody library

Despite major advances in antibody discovery technologies, the successful development of monoclonal antibodies (mAbs) into effective therapeutic and diagnostic agents can often be impeded by developability liabilities, such as poor expression, low solubility, high viscosity and aggregation. Therefor...

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Dettagli Bibliografici
Pubblicato in:MAbs
Autori principali: Wolf Pérez, Adriana-Michelle, Sormanni, Pietro, Andersen, Jonathan Sonne, Sakhnini, Laila Ismail, Rodriguez-Leon, Ileana, Bjelke, Jais Rose, Gajhede, Annette Juhl, De Maria, Leonardo, Otzen, Daniel E., Vendruscolo, Michele, Lorenzen, Nikolai
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2019
Soggetti:
Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6380425/
https://ncbi.nlm.nih.gov/pubmed/30523762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1556082
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