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Ofatumumab Monoclonal Antibody Affinity Maturation Through in silico Modeling

BACKGROUND: Ofatumumab, an anti-CD20 mAb, was approved in 2009 for the treatment of chronic lymphocytic leukemia. This mAb acts through immune-mediated mechanisms, in particular complement-dependent cytotoxicity and antibody-dependent cellular cytotoxicity by natural killer cells as well as antibody...

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Detalhes bibliográficos
Publicado no:Iran Biomed J
Main Authors: Payandeh, Zahra, Rajabibazl, Masoumeh, Mortazavi, Yousef, Rahimpour, Azam, Taromchi, Amir Hossein
Formato: Artigo
Idioma:Inglês
Publicado em: Pasteur Institute 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5889503/
https://ncbi.nlm.nih.gov/pubmed/28992681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.22034/ibj.22.3.180
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