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Affinity maturation of antibodies assisted by in silico modeling

Rational engineering methods can be applied with reasonable success to optimize physicochemical characteristics of proteins, in particular, antibodies. Here, we describe a combined CDR3 walking randomization and rational design-based approach to enhance the affinity of the human anti-gastrin TA4 scF...

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Bibliographische Detailangaben
Hauptverfasser: Barderas, Rodrigo, Desmet, Johan, Timmerman, Peter, Meloen, Rob, Casal, J. Ignacio
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2449359/
https://ncbi.nlm.nih.gov/pubmed/18574150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801221105
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