A Combinatorial Approach for the Design of Complementarity-determining Region-derived Peptidomimetics with in Vitro Anti-tumoral Activity

The great success of therapeutic monoclonal antibodies has fueled research toward mimicry of their binding sites and the development of new strategies for peptide-based mimetics production. Here, we describe a new combinatorial approach for the production of peptidomimetics using the complementarity...

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Autors principals: Timmerman, Peter, Barderas, Rodrigo, Desmet, Johan, Altschuh, Danièle, Shochat, Susana, Hollestelle, Martine J., Höppener, Jo W. M., Monasterio, Alberto, Casal, J. Ignacio, Meloen, Rob H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797183/
https://ncbi.nlm.nih.gov/pubmed/19808684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.041459
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