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Affinity maturation of antibodies assisted by in silico modeling
Rational engineering methods can be applied with reasonable success to optimize physicochemical characteristics of proteins, in particular, antibodies. Here, we describe a combined CDR3 walking randomization and rational design-based approach to enhance the affinity of the human anti-gastrin TA4 scF...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2449359/ https://ncbi.nlm.nih.gov/pubmed/18574150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801221105 |
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