Affinity maturation and characterization of a human monoclonal antibody against HIV-1 gp41

The human D5 monoclonal antibody binds to the highly conserved hydrophobic pocket on the N-terminal heptad repeat (NHR) trimer of HIV-1 gp41 and exhibits modest yet relatively broad neutralization activity. Both binding and neutralization depend on residues in the complementarity determining regions...

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Detalhes bibliográficos
Main Authors: Montgomery, Donna L, Wang, Ying-Jie, Hrin, Renee, Luftig, Micah, Su, Bin, Miller, Michael D, Wang, Fubao, Haytko, Peter, Huang, Lingyi, Vitelli, Salvatore, Condra, Jon, Liu, Xiaomei, Hampton, Richard, Carfi, Andrea, Pessi, Antonello, Bianchi, Elisabetta, Joyce, Joseph, Lloyd, Chris, Geleziunas, Romas, Bramhill, David, King, Vicki M, Finnefrock, Adam C, Strohl1, William, An, Zhiqiang
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2009
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2759496/
https://ncbi.nlm.nih.gov/pubmed/20065653
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