Vaccination with peptide mimetics of the gp41 prehairpin fusion intermediate yields neutralizing antisera against HIV-1 isolates

Eliciting a broadly neutralizing polyclonal antibody response against HIV-1 remains a major challenge. One approach to vaccine development is prevention of HIV-1 entry into cells by blocking the fusion of viral and cell membranes. More specifically, our goal is to elicit neutralizing antibodies that...

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Detalhes bibliográficos
Main Authors: Bianchi, Elisabetta, Joyce, Joseph G., Miller, Michael D., Finnefrock, Adam C., Liang, Xiaoping, Finotto, Marco, Ingallinella, Paolo, McKenna, Philip, Citron, Michael, Ottinger, Elizabeth, Hepler, Robert W., Hrin, Renee, Nahas, Deborah, Wu, Chengwei, Montefiori, David, Shiver, John W., Pessi, Antonello, Kim, Peter S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890830/
https://ncbi.nlm.nih.gov/pubmed/20483992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004261107
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