Small Molecule Mimetics of an HIV-1 gp41 Fusion Intermediate as Vaccine Leads

We describe here a novel platform technology for the discovery of small molecule mimetics of conformational epitopes on protein antigens. As a model system, we selected mimetics of a conserved hydrophobic pocket within the N-heptad repeat region of the HIV-1 envelope protein, gp41. The human monoclo...

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Autori principali: Caulfield, Michael J., Dudkin, Vadim Y., Ottinger, Elizabeth A., Getty, Krista L., Zuck, Paul D., Kaufhold, Robin M., Hepler, Robert W., McGaughey, Georgia B., Citron, Michael, Hrin, Renee C., Wang, Ying-Jie, Miller, Michael D., Joyce, Joseph G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2010
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3003359/
https://ncbi.nlm.nih.gov/pubmed/20943652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.172197
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