A human monoclonal antibody neutralizes diverse HIV-1 isolates by binding a critical gp41 epitope

HIV-1 entry into cells is mediated by the envelope glycoprotein receptor-binding (gp120) and membrane fusion-promoting (gp41) subunits. The gp41 heptad repeat 1 (HR1) domain is the molecular target of the fusion-inhibitor drug enfuvirtide (T20). The HR1 sequence is highly conserved and therefore con...

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Bibliografiska uppgifter
Huvudupphovsmän: Miller, Michael D., Geleziunas, Romas, Bianchi, Elisabetta, Lennard, Simon, Hrin, Renee, Zhang, Hangchun, Lu, Meiqing, An, Zhiqiang, Ingallinella, Paolo, Finotto, Marco, Mattu, Marco, Finnefrock, Adam C., Bramhill, David, Cook, James, Eckert, Debra M., Hampton, Richard, Patel, Mayuri, Jarantow, Stephen, Joyce, Joseph, Ciliberto, Gennaro, Cortese, Riccardo, Lu, Ping, Strohl, William, Schleif, William, McElhaugh, Michael, Lane, Steven, Lloyd, Christopher, Lowe, David, Osbourn, Jane, Vaughan, Tristan, Emini, Emilio, Barbato, Gaetano, Kim, Peter S., Hazuda, Daria J., Shiver, John W., Pessi, Antonello
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2005
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1253587/
https://ncbi.nlm.nih.gov/pubmed/16203977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506927102
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