A human monoclonal antibody neutralizes diverse HIV-1 isolates by binding a critical gp41 epitope

HIV-1 entry into cells is mediated by the envelope glycoprotein receptor-binding (gp120) and membrane fusion-promoting (gp41) subunits. The gp41 heptad repeat 1 (HR1) domain is the molecular target of the fusion-inhibitor drug enfuvirtide (T20). The HR1 sequence is highly conserved and therefore con...

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Detalhes bibliográficos
Main Authors: Miller, Michael D., Geleziunas, Romas, Bianchi, Elisabetta, Lennard, Simon, Hrin, Renee, Zhang, Hangchun, Lu, Meiqing, An, Zhiqiang, Ingallinella, Paolo, Finotto, Marco, Mattu, Marco, Finnefrock, Adam C., Bramhill, David, Cook, James, Eckert, Debra M., Hampton, Richard, Patel, Mayuri, Jarantow, Stephen, Joyce, Joseph, Ciliberto, Gennaro, Cortese, Riccardo, Lu, Ping, Strohl, William, Schleif, William, McElhaugh, Michael, Lane, Steven, Lloyd, Christopher, Lowe, David, Osbourn, Jane, Vaughan, Tristan, Emini, Emilio, Barbato, Gaetano, Kim, Peter S., Hazuda, Daria J., Shiver, John W., Pessi, Antonello
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1253587/
https://ncbi.nlm.nih.gov/pubmed/16203977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506927102
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