Characterization of gp120 and Its Single-Chain Derivatives, gp120-CD4(D12) and gp120-M9: Implications for Targeting the CD4(i) Epitope in Human Immunodeficiency Virus Vaccine Design

Single-chain derivatives of JRFL gp120 linked to the first two domains of human CD4 (gp120-CD4(D12)) or to the CD4 miniprotein analog CD4M9 (gp120-M9), have been constructed. Biacore studies revealed that gp120-CD4(D12) and gp120-M9 bound to antibody 17b with dissociation constants of 0.8 and 25 nM,...

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Detalhes bibliográficos
Main Authors: Varadarajan, Raghavan, Sharma, Deepak, Chakraborty, Kausik, Patel, Mayuri, Citron, Michael, Sinha, Prem, Yadav, Ramkishor, Rashid, Umar, Kennedy, Sarah, Eckert, Debra, Geleziunas, Romas, Bramhill, David, Schleif, William, Liang, Xiaoping, Shiver, John
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC544110/
https://ncbi.nlm.nih.gov/pubmed/15650196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.3.1713-1723.2005
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