2-Aminothiazolones as Anti-HIV Agents That Act as gp120-CD4 Inhibitors

We report here the synthesis of 2-aminothiazolones along with their biological properties as novel anti-HIV agents. Such compounds have proven to act through the inhibition of the gp120-CD4 protein-protein interaction that occurs at the very early stage of the HIV-1 entry process. No cytotoxicity wa...

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Dettagli Bibliografici
Autori principali: Tiberi, Marika, Tintori, Cristina, Ceresola, Elisa Rita, Fazi, Roberta, Zamperini, Claudio, Calandro, Pierpaolo, Franchi, Luigi, Selvaraj, Manikandan, Botta, Lorenzo, Sampaolo, Michela, Saita, Diego, Ferrarese, Roberto, Clementi, Massimo, Canducci, Filippo, Botta, Maurizio
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4068444/
https://ncbi.nlm.nih.gov/pubmed/24614386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02739-13
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