IgG2m4, an engineered antibody isotype with reduced Fc function

The Fc region of an antibody mediates effector functions such as antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC), and plays a key role in the in vivo half-life of an antibody. In designing antibody therapeutics, it is sometimes desirable that the anti...

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Detalhes bibliográficos
Main Authors: An, Zhiqiang, Forrest, Gail, Moore, Renee, Cukan, Michael, Haytko, Peter, Huang, Lingyi, Vitelli, Salvatore, Zhao, Jing Zhang, Lu, Ping, Hua, Jin, Gibson, Christopher R, Harvey, Barrett R, Montgomery, Donna, Zaller, Dennis, Wang, Fubao, Strohl, William
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791314/
https://ncbi.nlm.nih.gov/pubmed/20073128
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