Affinity maturation of a broadly neutralizing human monoclonal antibody that prevents acute HCV infection

Direct acting antivirals (DAAs) have led to a high cure rate in treated patients with chronic hepatitis C virus (HCV) infection but this still leaves a large number of treatment failures secondary to the emergence of resistance-associated variants (RAVs). To increase the barrier to resistance, a com...

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Vydáno v:Hepatology
Hlavní autoři: Keck, Zhen-Yong, Wang, Yong, Lau, Patrick, Lund, Garry, Rangarajan, Sneha, Fauvelle, Catherine, Liao, Grant C., Holtsberg, Frederick W., Warfield, Kelly L., Aman, M. Javad, Pierce, Brian G., Fuerst, Thomas R., Bailey, Justin R., Baumert, Thomas F., Mariuzza, Roy A., Kneteman, Norman M., Foung, Steven K. H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5115987/
https://ncbi.nlm.nih.gov/pubmed/27641232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.28850
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