Structural Basis for Penetration of the Glycan Shield of Hepatitis C Virus E2 Glycoprotein by a Broadly Neutralizing Human Antibody

Hepatitis C virus (HCV) is a major cause of liver cirrhosis and hepatocellular carcinoma. A challenge for HCV vaccine development is to identify conserved epitopes able to elicit protective antibodies against this highly diverse virus. Glycan shielding is a mechanism by which HCV masks such epitopes...

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Udgivet i:J Biol Chem
Main Authors: Li, Yili, Pierce, Brian G., Wang, Qian, Keck, Zhen-Yong, Fuerst, Thomas R., Foung, Steven K. H., Mariuzza, Roy A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4400327/
https://ncbi.nlm.nih.gov/pubmed/25737449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.643528
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