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Glycan Shielding and Modulation of Hepatitis C Virus Neutralizing Antibodies

Hepatitis C virus (HCV) envelope glycoprotein heterodimer, E1E2, plays an essential role in virus entry and assembly. Furthermore, due to their exposure at the surface of the virion, these proteins are the major targets of anti-HCV neutralizing antibodies. Their ectodomain are heavily glycosylated w...

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Pubblicato in:Front Immunol
Autori principali: Lavie, Muriel, Hanoulle, Xavier, Dubuisson, Jean
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5934428/
https://ncbi.nlm.nih.gov/pubmed/29755477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00910
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