Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline

There is strong evidence that obesity has deleterious effects on cognitive function of older adults. Previous preclinical studies demonstrate that obesity in aging is associated with a heightened state of systemic inflammation, which exacerbates blood–brain barrier disruption, promoting neuroinflamm...

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Veröffentlicht in:J Gerontol A Biol Sci Med Sci
Hauptverfasser: Valcarcel-Ares, Marta Noa, Tucsek, Zsuzsanna, Kiss, Tamas, Giles, Cory B, Tarantini, Stefano, Yabluchanskiy, Andriy, Balasubramanian, Priya, Gautam, Tripti, Galvan, Veronica, Ballabh, Praveen, Richardson, Arlan, Freeman, Willard M, Wren, Jonathan D, Deak, Ferenc, Ungvari, Zoltan, Csiszar, Anna
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2019
Schlagworte:
The Journal of Gerontology: Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6376091/
https://ncbi.nlm.nih.gov/pubmed/29893815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/gly127
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