Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood–Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype

Obesity has deleterious effects on cognitive function in the elderly adults. In mice, aging exacerbates obesity-induced oxidative stress, microvascular dysfunction, blood–brain barrier (BBB) disruption, and neuroinflammation, which compromise cognitive health. However, the specific mechanisms throug...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Gerontol A Biol Sci Med Sci
Main Authors: Tarantini, Stefano, Valcarcel-Ares, M Noa, Yabluchanskiy, Andriy, Tucsek, Zsuzsanna, Hertelendy, Peter, Kiss, Tamas, Gautam, Tripti, Zhang, Xin A, Sonntag, William E, de Cabo, Rafael, Farkas, Eszter, Elliott, Michael H, Kinter, Michael T, Deak, Ferenc, Ungvari, Zoltan, Csiszar, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
The Journal of Gerontology: Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6001893/
https://ncbi.nlm.nih.gov/pubmed/29905772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glx177
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados