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Nrf2 Deficiency Exacerbates Obesity-Induced Oxidative Stress, Neurovascular Dysfunction, Blood–Brain Barrier Disruption, Neuroinflammation, Amyloidogenic Gene Expression, and Cognitive Decline in Mice, Mimicking the Aging Phenotype

Obesity has deleterious effects on cognitive function in the elderly adults. In mice, aging exacerbates obesity-induced oxidative stress, microvascular dysfunction, blood–brain barrier (BBB) disruption, and neuroinflammation, which compromise cognitive health. However, the specific mechanisms throug...

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Bibliografiske detaljer
Udgivet i:J Gerontol A Biol Sci Med Sci
Main Authors: Tarantini, Stefano, Valcarcel-Ares, M Noa, Yabluchanskiy, Andriy, Tucsek, Zsuzsanna, Hertelendy, Peter, Kiss, Tamas, Gautam, Tripti, Zhang, Xin A, Sonntag, William E, de Cabo, Rafael, Farkas, Eszter, Elliott, Michael H, Kinter, Michael T, Deak, Ferenc, Ungvari, Zoltan, Csiszar, Anna
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6001893/
https://ncbi.nlm.nih.gov/pubmed/29905772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glx177
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