Obesity in Aging Exacerbates Neuroinflammation, Dysregulating Synaptic Function-Related Genes and Altering Eicosanoid Synthesis in the Mouse Hippocampus: Potential Role in Impaired Synaptic Plasticity and Cognitive Decline

There is strong evidence that obesity has deleterious effects on cognitive function of older adults. Previous preclinical studies demonstrate that obesity in aging is associated with a heightened state of systemic inflammation, which exacerbates blood–brain barrier disruption, promoting neuroinflamm...

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Udgivet i:J Gerontol A Biol Sci Med Sci
Main Authors: Valcarcel-Ares, Marta Noa, Tucsek, Zsuzsanna, Kiss, Tamas, Giles, Cory B, Tarantini, Stefano, Yabluchanskiy, Andriy, Balasubramanian, Priya, Gautam, Tripti, Galvan, Veronica, Ballabh, Praveen, Richardson, Arlan, Freeman, Willard M, Wren, Jonathan D, Deak, Ferenc, Ungvari, Zoltan, Csiszar, Anna
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
The Journal of Gerontology: Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6376091/
https://ncbi.nlm.nih.gov/pubmed/29893815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/gly127
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